Below is a list of publications (by primary author) that are fundamental to DIAN. As the study progresses, publications based upon DIAN's research will be posted here as well.

  1. Bateman RJ and Eidelberg D. Testing a test for Alzheimer disease. Neurology. 2007 Feb 13;68(7):482-3 (Links to a PDF)

  2. Bateman RJ, Munsell LY, Morris JC, Swarm R, Yarasheski KE, Holtzman DM. Human amyloid-ß synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nature Medicine. 2006 Jul;12(7):856-862 (Links to a PDF)

  3. Bateman RJ and Klunk WE. Measuring Target Effect of Proposed Disease-Modifying Therapies in Alzheimer's Disease. Neurotherapeutics. 2008 Jul;5(3):381-390 (Links to PDF)

  4. Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC. Dominantly Inherited Alzheimer Network. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med. 2012 Aug 30; 367 (9):795-804. Epub 2012 Jul 11. PMCID: PMC3474597 

  5. Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C.  Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther. 2011 Jan 6;3 (1):1. PMCID: PMC3109410 

  6. Brooks WS, Kwok JB, Halliday GM, Godbolt AK, Rossor MN, Creasey H, Jones AO, Schofield PR. Hemorrhage is uncommon in new Alzheimer family with Flemish amyloid precursor protein mutation. Neurology. 2004 Nov 9;63(9):1613-7

  7. Fagan AM, Head D, Shah AR, Marcus D, Mintun MA, Morris JC, Holtzman DM. Decreased Cerebrospinal Fluid Aß42 Correlates with Brain Atrophy in Cognitively Normal Elderly. Ann Neurol. 2009 February; 65(2): 176–183.

  8. Fagan AM, Mintun MA, Mach RH, Lee S, Dence CS, Shah AR, LaRossa GN, Spinner ML, Klunk WE, Mathis CA, DeKosky ST, Morris JC, Holtzman DM. Inverse Relation between In Vivo Amyloid Imaging Load and Cerebrospinal Fluid Aß42 in Humans. Ann Neurol 2006;59:512-519 (Links to PDF)

  9. Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal Fluid tau/ß-Amyloid42 Ratio as a Prediction of Cognitive Decline in Nondemented Older Adults. Arch Neurol 2007;64:343-349 (Links to a PDF)

  10. Fox NC, Crum WR, Scahill RI, Stevens JM, Janssen J, Rossor MN. Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images. Lancet. 2001 Jul 21;358(9277):201-5.

  11. Fox NC, Warrington EK, Freeborough PA Hartikainen P, Kennedy AM, Stevens JM and Rossor MN. Presymptomatic hippocampal atrophy in familial Alzheimer's disease: A longitudinal MRI study. Brain 1996 Dec;119 (Pt6):2001-7 

  12. Fox NC, Warrington EK, Rossor MN. Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer's disease. The Lancet 1999 Jun 19;353(9170):2125

  13. Fox NC, Warrington EK, Seiffer AL, Agnew SK, Rossor MN. Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease: a longitudinal prospective study. Brain 1998 Sep;121(Pt 9):1631-9

  14. Godbolt AK, Cipolotti L, Anderson VM, Archer H, Janssen JC, Price S, Rossor MN, Fox NC. A decade of pre-diagnostic assessment in a case of familial Alzheimer's disease: tracking progression from asymptomatic to MCI and dementia. Neurocase. 2005 Feb;11(1):56-64

  15. Gregory GC, Macdonald V, Schofield PR, Kril JJ, Halliday GM. Differences in regional brain atrophy in genetic forms of Alzheimer's disease. Neurobiol Aging. 2006 Mar;27(3):387-93

  16. Halliday GM, Song YJ, Lepar G, Brooks WS, Kwok JB, Kersaitis C, Gregory G, Shepherd CE, Rahimi F, Schofield PR, Kril JJ. Pick bodies in a family with presenilin-1 Alzheimer's disease. Ann Neurol. 2005 Jan;57(1):139-43

  17. Karlstrom H, Brooks WS, Kwok JB, Broe GA, Kril JJ, McCann H, Halliday GM, Schofield PR. Variable phenotype of Alzheimer's disease with spastic paraparesis. J Neurochem. 2008 Feb;104(3):573-83

  18. Karlstrom H, Kwok JB, Gregory GC, Hallupp M, Brooks WS, Schofield PR. No association of spastic paraparesis genes in PSEN1 Alzheimer's disease with spastic paraparesis. Neuroreport. 2007 Aug 6;18(12):1267-9

  19. Kwok JB, Halliday GM, Brooks WS, Dolios G, Laudon H, Murayama O, Hallupp M, Badenhop RF, Vickers J, Wang R, Naslund J, Takashima A, Gandy SE, Schofield PR. Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy. J Biol Chem. 2003 Feb 28;278(9):6748-54

  20. Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Gilbert PE, Liang LJ, Cummings JL, Ringman JM. Propositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2011;32(3):188-92. Epub 2011 Aug 30. 

  21. Mintun MA, LaRossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC. [11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease. Neurology. 2006;67:446-452 (Links to a PDF)

  22. Morris JC, Aisen PS, Bateman RJ, Benzinger T, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, Oliver A, Quaid K, Ringman JM, Rossor MN, Salloway S, Schofield PR, Selsor NJ, Sperling RA, Weiner MW, Xiong C, Moulder KL, Buckles VD. Developing an international network for Alzheimer’s research: the Dominantly Inherited Alzheimer Network.  Clin Investig (Lond). 2012 Oct 1;2(10):975-984. PMCID: PMC3489185 

  23. Panegyres PK, Kwok JB, Schofield PR, Blumbergs PC. A Western Australian kindred with Dutch cerebral amyloid angiopathy. J Neurol Sci. 2005 Dec 15;239(1):75-80

  24. Ridha BH, Barnes J, Bartlett JW, Godbolt A, Pepple T, Rossor MN, Fox NC. Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study. Lancet Neurology 2006 Oct;5(10):828-34

  25. Ringman JM, Diaz-Olavarrieta C, Rodriguez Y, Chavez M, Fairbanks L, Paz F, Varpetian A, Maldonado HC, Macias-Islas MA, Murrell J, Ghetti B, Kawas C. Neuropsychological function in nondemented carriers of presenilin-1 mutations. Neurology. 2005 Aug 23;65(4):552-8. (Links to PDF)

  26. Ringman J.M., O’Neill J., Geschwind D., Medina L., Apostolova L.G., Rodriguez Y., Schaffer B., Varpetian A., Tseng B., Ortiz F., Fitten J., Cummings JL, Bartzokis G. Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutation. Brain Advance Access published on July 1, 2007, DOI 10.1093/brain/awm102. Brain 130: 1767-1776 (Links to PDF)

  27. Ringman, J. M., Younkin, S. G., Pratico, D., Seltzer, W., Cole, G. M., Geschwind, D. H., Rodriguez-Agudelo, Y., Schaffer, B., Fein, J., Sokolow, S., Rosario, E. R., Gylys, K. H., Varpetian, A., Medina, L. D., Cummings, J. L. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology 2008 71: 85-92. (Links to PDF)

  28. Ringman JM, Grill J, Rodriguez-Agudelo Y, Chavez M, Xiong C. Commentary on "a roadmap for the prevention of dementia II: Leon Thal Symposium 2008." Prevention trials in persons at risk for dominantly inherited Alzheimer's disease: opportunities and challenges. Alzheimers Dement. 2009 Mar;5 (2):166-71. Review. 

  29. Scahill RI, Schott JM, Stevens JM, Rossor MN, Fox NC. Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI. Proceedings of the National Academy of Science 2002 Apr;99(7):4703-7

  30. Shepherd CE, Gregory GC, Vickers JC, Brooks WS, Kwok JB, Schofield PR, Kril JJ, Halliday GM. Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques. Neurobiol Dis. 2004 Feb;15(1):115-9

  31. Smith MJ, Kwok JB, McLean CA, Kril JJ, Broe GA, Nicholson GA, Cappai R, Hallupp M, Cotton RG, Masters CL, Schofield PR, Brooks WS. Variable phenotype of Alzheimer's disease with spastic paraparesis. Ann Neurol. 2001 Jan;49(1):125-9

  32. Snider BJ, Norton J, Coats MA, Chakraverty S, Hou CE, Jervis R, Lendon CL, Goate AM, McKeel DW, Morris JC. Novel Presenilin 1 Mutation (S170F) Causing Alzheimers Disease With Lewy Bodies in the Third Decade of Life. Arch Neurol. 2005;62:1821-1830 (Links to a PDF)